CovidChloroV1, Main, Exploration, bibRecord, 000B80

Systematic Review and Pharmacological Considerations for Chloroquine and Its Analogs in the Treatment for COVID-19.

Identifieur interne : 000B80 ( Main/Exploration ); précédent : 000B79; suivant : 000B81

Systematic Review and Pharmacological Considerations for Chloroquine and Its Analogs in the Treatment for COVID-19.

Source :

Frontiers in pharmacology [ 1663-9812 ] ; 2020.

RBID : pubmed:33192503

Abstract

COVID-19 has been announced pandemic by WHO and over 17,000,000 people infected (Till April 21st 2020). The disease is currently under control in China, with a curative rate of 86.8%. Chloroquine (CQ) is an old anti-malarial drug with good tolerability, which had proved to be effective in previous SARS-coronavirus, which spread and disappeared between 2002-2003. In vitro studies demonstrated the efficacy of CQ in curing COVID-19. Consequently, via analytical PBPK modeling, a further preliminary clinical trial has proved the efficacy and safety of CQ in China., and multiple clinical trials were registered and approved to investigate the activity of other analogs of CQ against COVID-19. We have listed all the clinical trials and made a meta-analysis of published data of hydroxychloroquine (HCQ). HCQ could increase the CT improvement and adverse reactions (ADRs) significantly though there was considerable heterogeneity among current researches. Actually, CQ and its analogs have unique pharmacokinetic characteristics, which would induce severe side effects in some circumstances. We have then summarized pharmacological considerations for these drugs so as to provide to the busy clinicians to avoid potential side effects when administered CQ or its analogs to COVID-19 patients, especially in the elderly, pediatrics, and pregnancies.

DOI: 10.3389/fphar.2020.554172
PubMed: 33192503
PubMed Central: PMC7655531

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000833
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Le document en format XML

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<author><name sortKey="Lai, Xin" sort="Lai, Xin" uniqKey="Lai X" first="Xin" last="Lai">Xin Lai</name>
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<author><name sortKey="Wen, Jinhua" sort="Wen, Jinhua" uniqKey="Wen J" first="Jinhua" last="Wen">Jinhua Wen</name>
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<author><name sortKey="Zhao, Mengjun" sort="Zhao, Mengjun" uniqKey="Zhao M" first="Mengjun" last="Zhao">Mengjun Zhao</name>
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<author><name sortKey="Zeng, Chuanfei" sort="Zeng, Chuanfei" uniqKey="Zeng C" first="Chuanfei" last="Zeng">Chuanfei Zeng</name>
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<author><name sortKey="Du, Lijuan" sort="Du, Lijuan" uniqKey="Du L" first="Lijuan" last="Du">Lijuan Du</name>
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<author><name sortKey="Zhang, Yanmei" sort="Zhang, Yanmei" uniqKey="Zhang Y" first="Yanmei" last="Zhang">Yanmei Zhang</name>
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<author><name sortKey="Hu, Jinfang" sort="Hu, Jinfang" uniqKey="Hu J" first="Jinfang" last="Hu">Jinfang Hu</name>
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<author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name>
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<author><name sortKey="Chen, Zhangren" sort="Chen, Zhangren" uniqKey="Chen Z" first="Zhangren" last="Chen">Zhangren Chen</name>
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<author><name sortKey="Xu, Tiantian" sort="Xu, Tiantian" uniqKey="Xu T" first="Tiantian" last="Xu">Tiantian Xu</name>
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<author><name sortKey="Lai, Xin" sort="Lai, Xin" uniqKey="Lai X" first="Xin" last="Lai">Xin Lai</name>
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<author><name sortKey="Wen, Jinhua" sort="Wen, Jinhua" uniqKey="Wen J" first="Jinhua" last="Wen">Jinhua Wen</name>
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<author><name sortKey="Zhao, Mengjun" sort="Zhao, Mengjun" uniqKey="Zhao M" first="Mengjun" last="Zhao">Mengjun Zhao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First Clinical Medical College of Nanchang University, Nanchang</wicri:regionArea>
<placeName><settlement type="city">Nanchang</settlement>
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</placeName>
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<author><name sortKey="Zeng, Chuanfei" sort="Zeng, Chuanfei" uniqKey="Zeng C" first="Chuanfei" last="Zeng">Chuanfei Zeng</name>
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<wicri:regionArea>The First Clinical Medical College of Nanchang University, Nanchang</wicri:regionArea>
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</placeName>
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<author><name sortKey="Du, Lijuan" sort="Du, Lijuan" uniqKey="Du L" first="Lijuan" last="Du">Lijuan Du</name>
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<wicri:regionArea>The First Clinical Medical College of Nanchang University, Nanchang</wicri:regionArea>
<placeName><settlement type="city">Nanchang</settlement>
<region type="province">Jiangxi</region>
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<author><name sortKey="Zhang, Yanmei" sort="Zhang, Yanmei" uniqKey="Zhang Y" first="Yanmei" last="Zhang">Yanmei Zhang</name>
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<author><name sortKey="Cao, Li" sort="Cao, Li" uniqKey="Cao L" first="Li" last="Cao">Li Cao</name>
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<author><name sortKey="Hu, Jinfang" sort="Hu, Jinfang" uniqKey="Hu J" first="Jinfang" last="Hu">Jinfang Hu</name>
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</placeName>
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<author><name sortKey="Wei, Xiaohua" sort="Wei, Xiaohua" uniqKey="Wei X" first="Xiaohua" last="Wei">Xiaohua Wei</name>
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<wicri:regionArea>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang</wicri:regionArea>
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<author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang</wicri:regionArea>
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<series><title level="j">Frontiers in pharmacology</title>
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<imprint><date when="2020" type="published">2020</date>
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<front><div type="abstract" xml:lang="en">COVID-19 has been announced pandemic by WHO and over 17,000,000 people infected (Till April 21st 2020). The disease is currently under control in China, with a curative rate of 86.8%. Chloroquine (CQ) is an old anti-malarial drug with good tolerability, which had proved to be effective in previous SARS-coronavirus, which spread and disappeared between 2002-2003. In vitro studies demonstrated the efficacy of CQ in curing COVID-19. Consequently, <i>via</i>
 analytical PBPK modeling, a further preliminary clinical trial has proved the efficacy and safety of CQ in China., and multiple clinical trials were registered and approved to investigate the activity of other analogs of CQ against COVID-19. We have listed all the clinical trials and made a meta-analysis of published data of hydroxychloroquine (HCQ). HCQ could increase the CT improvement and adverse reactions (ADRs) significantly though there was considerable heterogeneity among current researches. Actually, CQ and its analogs have unique pharmacokinetic characteristics, which would induce severe side effects in some circumstances. We have then summarized pharmacological considerations for these drugs so as to provide to the busy clinicians to avoid potential side effects when administered CQ or its analogs to COVID-19 patients, especially in the elderly, pediatrics, and pregnancies.</div>
</front>
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<Month>11</Month>
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<Title>Frontiers in pharmacology</Title>
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<ELocationID EIdType="doi" ValidYN="Y">10.3389/fphar.2020.554172</ELocationID>
<Abstract><AbstractText>COVID-19 has been announced pandemic by WHO and over 17,000,000 people infected (Till April 21st 2020). The disease is currently under control in China, with a curative rate of 86.8%. Chloroquine (CQ) is an old anti-malarial drug with good tolerability, which had proved to be effective in previous SARS-coronavirus, which spread and disappeared between 2002-2003. In vitro studies demonstrated the efficacy of CQ in curing COVID-19. Consequently, <i>via</i>
 analytical PBPK modeling, a further preliminary clinical trial has proved the efficacy and safety of CQ in China., and multiple clinical trials were registered and approved to investigate the activity of other analogs of CQ against COVID-19. We have listed all the clinical trials and made a meta-analysis of published data of hydroxychloroquine (HCQ). HCQ could increase the CT improvement and adverse reactions (ADRs) significantly though there was considerable heterogeneity among current researches. Actually, CQ and its analogs have unique pharmacokinetic characteristics, which would induce severe side effects in some circumstances. We have then summarized pharmacological considerations for these drugs so as to provide to the busy clinicians to avoid potential side effects when administered CQ or its analogs to COVID-19 patients, especially in the elderly, pediatrics, and pregnancies.</AbstractText>
<CopyrightInformation>Copyright © 2020 Peng, Chen, Wang, Ren, Xu, Lai, Wen, Zhao, Zeng, Du, Zhang, Cao, Hu, Wei and Hong.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Hongwei</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Zhangren</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yunyun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Academic Affairs Office, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Simei</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Tiantian</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lai</LastName>
<ForeName>Xin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Jinhua</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Mengjun</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The First Clinical Medical College of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Chuanfei</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>The First Clinical Medical College of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Du</LastName>
<ForeName>Lijuan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>The First Clinical Medical College of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yanmei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The First Clinical Medical College of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Jinfang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Xiaohua</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hong</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>10</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Front Pharmacol</MedlineTA>
<NlmUniqueID>101548923</NlmUniqueID>
<ISSNLinking>1663-9812</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">chloroquine</Keyword>
<Keyword MajorTopicYN="N">hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">pharmacological considerations</Keyword>
<Keyword MajorTopicYN="N">piperaquine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>11</Month>
<Day>16</Day>
<Hour>8</Hour>
<Minute>44</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>11</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>11</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>1</Minute>
</PubMedPubDate>
</History>
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<ArticleIdList><ArticleId IdType="pubmed">33192503</ArticleId>
<ArticleId IdType="doi">10.3389/fphar.2020.554172</ArticleId>
<ArticleId IdType="pmc">PMC7655531</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Am Geriatr Soc. 2020 May;68(5):926-929</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32255507</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2020 Jun;145(6):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32179660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Pharmacol Ther. 2020 Aug;108(2):248-252</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32320477</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Toxicol Pharmacol. 2010 Sep;30(2):103-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21787638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Dis. 2018 Feb;110:68-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29196214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Pharmacol. 1997;52(4):299-305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9248769</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Gastroenterol Hepatol. 2020 Jun;18(7):1561-1566</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32283325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(1):139-146</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32064795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Regul Toxicol Pharmacol. 2019 Dec;109:104486</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31580888</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Heart Fail Rev. 2015 Mar;20(2):179-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25030479</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):185-188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32164085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med (N Y). 2020 Jun 5;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32838355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Antimicrob Chemother. 2015;70(6):1608-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25693996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1849</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Cardiol Rep. 2020 Apr 14;22(5):31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32291526</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Gynaecol Obstet. 2019 Jul;146(1):43-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31050803</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Saf. 2018 Oct;41(10):919-931</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29858838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hong Kong Med J. 2006 Aug;12(4):294-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16912357</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Malar J. 2011 Jul 20;10:198</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21774826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2012 Jul 11;345:e4260</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22786934</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Drug Investig. 2015 Sep;35(9):559-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26293519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Pharmacokinet. 1996 Oct;31(4):257-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8896943</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Lett. 2018 Aug;16(2):2613-2619</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30013656</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Malar J. 2012 Nov 29;11:398</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23190801</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Allergy Clin Immunol. 2020 Jul;146(1):110-118</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32294485</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2008 Mar;52(3):1052-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18180343</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Xenobiotica. 2012 Nov;42(11):1088-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22671777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Respir Med. 2020 May;8(5):e29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32222167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cardiovasc Pathol. 2002 Sep-Oct;11(5):277-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12361838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2017 Apr 24;61(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28193647</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pharm Res. 2003 Aug;26(8):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12967198</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Jul 1;5(7):825-830</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32324209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ophthalmology. 2016 Jun;123(6):1386-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26992838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1988 Jan 7;318(1):1-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3336379</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharm Sci. 2016 Feb;105(2):884-890</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26429523</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheumatol. 2016 Jan;68(1):184-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26316040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Crit Care. 2020 Jun;57:279-283</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32173110</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Clin Pharmacol. 2017 Dec;83(12):2752-2766</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28695570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2010 Aug;45(8):3245-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20466465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2020 Apr 16;181(2):271-280.e8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32142651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):745-756</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28070879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circ Res. 2020 Jun 5;126(12):1671-1681</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302265</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ned Tijdschr Geneeskd. 2018 Dec 17;163:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30570930</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Jiangxi</li>
</region>
<settlement><li>Nanchang</li>
<li>Pékin</li>
</settlement>
</list>
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<name sortKey="Chen, Zhangren" sort="Chen, Zhangren" uniqKey="Chen Z" first="Zhangren" last="Chen">Zhangren Chen</name>
<name sortKey="Du, Lijuan" sort="Du, Lijuan" uniqKey="Du L" first="Lijuan" last="Du">Lijuan Du</name>
<name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name>
<name sortKey="Hu, Jinfang" sort="Hu, Jinfang" uniqKey="Hu J" first="Jinfang" last="Hu">Jinfang Hu</name>
<name sortKey="Lai, Xin" sort="Lai, Xin" uniqKey="Lai X" first="Xin" last="Lai">Xin Lai</name>
<name sortKey="Ren, Simei" sort="Ren, Simei" uniqKey="Ren S" first="Simei" last="Ren">Simei Ren</name>
<name sortKey="Ren, Simei" sort="Ren, Simei" uniqKey="Ren S" first="Simei" last="Ren">Simei Ren</name>
<name sortKey="Ren, Simei" sort="Ren, Simei" uniqKey="Ren S" first="Simei" last="Ren">Simei Ren</name>
<name sortKey="Wang, Yunyun" sort="Wang, Yunyun" uniqKey="Wang Y" first="Yunyun" last="Wang">Yunyun Wang</name>
<name sortKey="Wei, Xiaohua" sort="Wei, Xiaohua" uniqKey="Wei X" first="Xiaohua" last="Wei">Xiaohua Wei</name>
<name sortKey="Wen, Jinhua" sort="Wen, Jinhua" uniqKey="Wen J" first="Jinhua" last="Wen">Jinhua Wen</name>
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Systematic Review and Pharmacological Considerations for Chloroquine and Its Analogs in the Treatment for COVID-19.

Systematic Review and Pharmacological Considerations for Chloroquine and Its Analogs in the Treatment for COVID-19.

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